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This loop proves to be even more powerful than initially thought, asadditional multiple regulatory loops are being found to interweave with it [15–19].Several of these loops will be described in this chapter. In this important sense, the cell cycle, apop-tosis, senescence and carcinogenesis have to be all seenas intimately related biological processes In this important sense, the cell cycle, apop-tosis, senescence and carcinogenesis have to be all seenas intimately related biological processes. Zhang CK, Stein PB, Liu J, Wang Z, Yang R, Cho JH, Gregersen PK, Aerts JM, Zhao H,Pastores GM, Mistry PK (2012) Genome-wide association study of N370S homozygousGaucher disease reveals the candidacy of CLN8 gene as a genetic modi?er contributing toextreme phenotypic variation. He viewed these as turning points wherein increasedvulnerability and enhanced potential were presented to aperson during each stage.
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